Betacellulin induces angiogenesis through activation of mitogen‐activated protein kinase and phosphatidylinositol 3’‐kinase in endothelial cells

@article{SukKim2003BetacellulinIA,
  title={Betacellulin induces angiogenesis through activation of mitogen‐activated protein kinase and phosphatidylinositol 3’‐kinase in endothelial cells},
  author={Hoe Suk Kim and Hyoung Seek Shin and Hee Jin Kwak and Chung-Hyun Cho and Chin O. Lee and Gou Young Koh},
  journal={The FASEB Journal},
  year={2003},
  volume={17}
}
Betacellulin (BTC) is a member of the epidermal growth factor (EGF) family, and it acts through EGF receptors. We asked whether BTC could be an angiogenic factor. Using human umbilical vein endothelial cells (HUVECs), we examined the effect of BTC on kinases and angiogenic processes. BTC induced ERK1/2 and Akt phosphorylation in a dose‐ and time‐dependent manner. BTC induced phosphorylation of all three EGF receptors present on HUVECs: ErbB2, ErbB3, and ErbB4. Pretreatment with effective… 
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It is shown that TSP1 opens the paracellular pathway in human lung microvascular endothelial cells (HMVEC-Ls) in a dose, time, and protein tyrosine kinase (PTK)-dependent manner and disrupts the endothelial barrier through EGFR/ErbB2 activation although additional signals are necessary in cells with low receptor expression.
ErbB Ligands in Angiogenesis
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