Betacellulin enhances ovarian cancer cell migration by up-regulating Connexin43 via MEK-ERK signaling.

@article{Zhao2019BetacellulinEO,
  title={Betacellulin enhances ovarian cancer cell migration by up-regulating Connexin43 via MEK-ERK signaling.},
  author={Jianfang Zhao and Christian Klausen and Yuyin Yi and Jung-Chien Cheng and Hsun‐Ming Chang and Peter C. K. Leung},
  journal={Cellular signalling},
  year={2019},
  pages={
          109439
        }
}
Sitagliptin Modulates the Response of Ovarian Cancer Cells to Chemotherapeutic Agents
TLDR
The obtained data showed that sitagliptin used with paclitaxel may be considered as a possibility of pharmacological modulation of intracellular transmission pathways to improve the response to chemotherapy.
Connexins in Cancer: Jekyll or Hyde?
TLDR
It is proposed that connexins function upstream of most, if not all, of the hallmarks of cancer and the development of advanced connexin targeting approaches remains an opportunity for the field to further interrogate the role of con Nexins in cancer phenotypes.

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The results suggest that betacellulin induces ovarian cancer migration and Slug-dependent E-cadherin down-regulation via EGFR-mediated MEK-ERK and PI3K-Akt signaling.
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