Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis.

  title={Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis.},
  author={Andrea Bertotti and Paolo Maria Comoglio and Livio Trusolino},
  journal={Cancer research},
  volume={65 23},
Cell multiplication in the absence of integrin-derived adhesive signals (anchorage-independent growth) is the phenotypic hallmark of neoplastic transformation. Therefore, the frequently observed up-regulation of some integrins in tumors has been interpreted as an epiphenomenon and not as a causative factor of oncogenic conversion. beta4 integrin stimulates proliferation and survival of epithelial cells and is overexpressed in human carcinomas, often in concomitance with up-regulation of the Met… CONTINUE READING


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