Beta3-integrin regulates vascular endothelial growth factor-A-dependent permeability.

  title={Beta3-integrin regulates vascular endothelial growth factor-A-dependent permeability.},
  author={Stephen D Robinson and Louise E Reynolds and Lorenza Wyder and Daniel J. Hicklin and Kairbaan M Hodivala-Dilke},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={24 11},
OBJECTIVE Beta3-integrin deficiency has been implicated in increasing levels of Flk-1 expression on endothelial cells and enhancing vascular endothelial growth factor (VEGF)-induced angiogenesis. We determined the role of beta3-integrin in mediating VEGF-A-induced blood vessel permeability through Flk-1. METHODS AND RESULTS Using the Miles assay, we demonstrated that VEGF-A-induced plasma leakage was enhanced in beta3-null mice when compared with wild-type controls. This was not caused by any… CONTINUE READING


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