Beta3-integrin regulates vascular endothelial growth factor-A-dependent permeability.

@article{Robinson2004Beta3integrinRV,
  title={Beta3-integrin regulates vascular endothelial growth factor-A-dependent permeability.},
  author={Stephen D Robinson and Louise E Reynolds and Lorenza Wyder and Daniel J. Hicklin and Kairbaan M Hodivala-Dilke},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2004},
  volume={24 11},
  pages={2108-14}
}
OBJECTIVE Beta3-integrin deficiency has been implicated in increasing levels of Flk-1 expression on endothelial cells and enhancing vascular endothelial growth factor (VEGF)-induced angiogenesis. We determined the role of beta3-integrin in mediating VEGF-A-induced blood vessel permeability through Flk-1. METHODS AND RESULTS Using the Miles assay, we demonstrated that VEGF-A-induced plasma leakage was enhanced in beta3-null mice when compared with wild-type controls. This was not caused by any… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…