Beta3-integrin-mediated focal adhesion complex formation: adult cardiocytes embedded in three-dimensional polymer matrices.

@article{Nagai1999Beta3integrinmediatedFA,
  title={Beta3-integrin-mediated focal adhesion complex formation: adult cardiocytes embedded in three-dimensional polymer matrices.},
  author={Tomoo Nagai and Martin Laser and Catalin F. Baicu and Michael R. Zile and George Cooper and Dhandapani Kuppuswamy},
  journal={The American journal of cardiology},
  year={1999},
  volume={83 12A},
  pages={38H-43H}
}
In vivo studies show that beta3-integrin-mediated focal adhesion formation (FAF) causes recruitment of nonreceptor tyrosine kinases to the cytoskeleton in pressure-overloaded myocardium. To define the mechanism of beta3-integrin-mediated signaling, we developed a cell culture model (adult feline cardiocytes embedded in a 3-dimensional matrix of native type 1 collagen, fibronectin, and vitronectin) wherein beta3-integrin-mediated focal adhesion kinase occurs. Focal adhesion kinase was analyzed… CONTINUE READING
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