Beta2 integrins (CD11/CD18) promote apoptosis of human neutrophils.

@article{Walzog1997Beta2I,
  title={Beta2 integrins (CD11/CD18) promote apoptosis of human neutrophils.},
  author={Barbara Walzog and F Jeblonski and Andreas Zakrzewicz and Peter A. L. Gaehtgens},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1997},
  volume={11 13},
  pages={1177-86}
}
Apoptosis of human polymorphonuclear neutrophils (PMN) is thought to be critical for the control of the inflammatory process, but the mechanisms underlying its regulation in physiological settings are still incompletely understood. This study was undertaken to test the hypothesis that the beta2 integrin (CD11/CD18) family of leukocyte adhesion molecules contributes to the control of activated PMN by up-regulating apoptosis. Apoptosis of isolated human PMN was investigated by 1) analysis of DNA… CONTINUE READING

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The effect required aggregation of the beta2 integrin Mac-1 ( CD11b / CD18 ) , which was induced by antibody cross - linking , and was independent of Fc receptors .
The effect required aggregation of the beta2 integrin Mac-1 ( CD11b / CD18 ) , which was induced by antibody cross - linking , and was independent of Fc receptors .
The effect required aggregation of the beta2 integrin Mac-1 ( CD11b / CD18 ) , which was induced by antibody cross - linking , and was independent of Fc receptors .
The effect required aggregation of the beta2 integrin Mac-1 ( CD11b / CD18 ) , which was induced by antibody cross - linking , and was independent of Fc receptors .
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