Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model.

@article{Nguyen2009Beta2adrenoceptorSI,
  title={Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model.},
  author={Long P. Nguyen and Rui Lin and Sergio Estrada Parra and Ozozoma Omoluabi and Nicola Alexander Hanania and Michael J. Tuvim and Brian J. Knoll and Burton F Dickey and Richard A. Bond},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 7},
  pages={2435-40}
}
Chronic regular use of beta(2)-adrenoceptor (beta(2)-AR) agonists in asthma is associated with a loss of disease control and increased risk of death. Conversely, we have found that administration of beta(2)-AR inverse agonists results in attenuation of the asthma phenotype in an allergen-driven murine model. Besides antagonizing agonist-induced signaling and reducing signaling by empty receptors, beta-AR inverse agonists can also activate signaling by novel pathways. To determine the mechanism… CONTINUE READING

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