Beta1-integrins partly mediate binding of ovarian cancer cells to peritoneal mesothelium in vitro.

@article{Strobel1999Beta1integrinsPM,
  title={Beta1-integrins partly mediate binding of ovarian cancer cells to peritoneal mesothelium in vitro.},
  author={Thomas Strobel and Stephen A. Cannistra},
  journal={Gynecologic oncology},
  year={1999},
  volume={73 3},
  pages={362-7}
}
Ovarian cancer cells frequently metastasize by implanting onto the peritoneal mesothelial surface of the abdominal cavity. Although the CD44 molecule expressed by ovarian cancer cells is known to partly mediate this process, the role of other adhesion proteins such as beta1-integrins has been previously difficult to demonstrate using the 4B4 anti-beta1 neutralizing antibody. In view of the widespread expression of beta1-integrins in ovarian cancer, however, we have further examined the… CONTINUE READING
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