Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis.

@article{Tanjore2008Beta1IE,
  title={Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis.},
  author={Harikrishna Tanjore and Elisabeth M. Zeisberg and Behzad Gerami-Naini and Raghu Kalluri},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2008},
  volume={237 1},
  pages={75-82}
}
Integrins are a family of cell adhesion receptors that are involved in cell-matrix and cell-cell communications. They facilitate cell proliferation, migration, and survival. Using the Cre-Lox system, we deleted beta1 integrin on Tie2-positive (Tie2-cre beta1 Int (fl/fl)) vascular endothelial cells. Deletion of beta1 integrin on vascular endothelial cells results in embryonic lethality. Blood vessel defects are encountered in the Tie2-Cre beta1 Int (fl/fl) embryos at embryonic age (E9.5), and… CONTINUE READING