Beta-thalassaemia: emergence of new and improved iron chelators for treatment.

  title={Beta-thalassaemia: emergence of new and improved iron chelators for treatment.},
  author={Cynthia Mei-Yuk Wong and Des. R. Richardson},
  journal={The international journal of biochemistry & cell biology},
  volume={35 7},
Beta-thalassaemia is an inherited blood disorder which through repeated blood transfusions and enhanced iron uptake from the gastrointestinal tract, results in marked iron overload. Untreated, the iron accumulation results in the dysfunction of vital organs such as the heart and liver. At present, the most effective treatment for beta-thalassaemia is the use of the iron chelator, desferrioxamine, which is expensive, orally inactive and requires long subcutaneous infusions. In this concise… CONTINUE READING


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