Beta-subunits are important modulators of the acute response to alcohol in human BK channels.

@article{FeinbergZadek2007BetasubunitsAI,
  title={Beta-subunits are important modulators of the acute response to alcohol in human BK channels.},
  author={Paula Leslie Feinberg-Zadek and Steven N. Treistman},
  journal={Alcoholism, clinical and experimental research},
  year={2007},
  volume={31 5},
  pages={
          737-44
        }
}
BACKGROUND The BK channel (a Ca2+-activated potassium ion channel encoded by the slo gene) has been defined as a target of alcohol action in a number of preparations, possibly serving as primary mediator of intoxication in the Caenorhabditis elegans model system. However, we know little of the actions of alcohol on human BK, nor the consequences of BK subunit composition on alcohol action. METHODS Here, we use human embryonic kidney (HEK) cells to express various subunit combinations (hslo… CONTINUE READING
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