Beta-subunit-dependent modulation of hSlo BK current by arachidonic acid.

  title={Beta-subunit-dependent modulation of hSlo BK current by arachidonic acid.},
  author={Xiaolu Sun and D Zhou and Peng Zhang and Edward G. Moczydlowski and Gabriel G. Haddad},
  journal={Journal of neurophysiology},
  volume={97 1},
In this study, we examined the effect of arachidonic acid (AA) on the BK alpha-subunit with or without beta-subunits expressed in Xenopus oocytes. In excised patches, AA potentiated the hSlo-alpha current and slowed inactivation only when beta2/3 subunit was co-expressed. The beta2-subunit-dependent modulation by AA persisted in the presence of either superoxide dismutase or inhibitors of AA metabolism such as nordihydroguaiaretic acid and eicosatetraynoic acid, suggesting that AA acts directly… CONTINUE READING
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