Beta-substituted ethylsulfonyl chlorides as 5'-OH protecting groups in nucleoside and nucleotide chemistry.

Abstract

Three beta-substituted ethylsulfonyl chlorides 1-3 were synthesized and their usefulness as 5'-OH protecting groups for oligonucleotide synthesis studied. The formation of the corresponding 5'-beta-R-ethyl-sulfonic acid esters was investigated in respect to fast and complete capping. The 5'-sulfonates 4-9 were prepared and the deprotection was studied using… (More)

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