Corpus ID: 45192723

Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits.

@article{Chacn2004BetasheetBP,
  title={Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits.},
  author={M. Chac{\'o}n and M. I. Barria and C. Soto and N. Inestrosa},
  journal={Molecular psychiatry},
  year={2004},
  volume={9 10},
  pages={
          953-61
        }
}
Current evidence supports the notion that beta-amyloid deposits or Abeta intermediates may be responsible for the pathogenesis in Alzheimer's disease (AD) patients. In the present work, we have assessed the neuroprotective effect of the chronic intraperitoneal administration of a five-amino-acid beta-sheet breaker peptide (iAbeta5p) on the rat behavioral deficit induced by the intrahippocampal Abeta-fibrils injection. At 1 month after the injection, animals showed a partial reduction of the… Expand
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