Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors.

@article{Mancini2011BetasecretaseAA,
  title={Beta-secretase as a target for Alzheimer's disease drug discovery: an overview of in vitro methods for characterization of inhibitors.},
  author={Francesca Romana Mancini and Angela De Simone and Vincenza Andrisano},
  journal={Analytical and bioanalytical chemistry},
  year={2011},
  volume={400 7},
  pages={1979-96}
}
β-Secretase 1 (BACE1) is the enzyme involved in the abnormal production of the amyloidogenic peptide Aβ42, one of the major causes of histological hallmarks of Alzheimer's disease. Thus, BACE1 represents a key target protein in the development of new potential drugs for the non-symptomatic treatment of Alzheimer's disease. Since the discovery of BACE1 one decade ago, both in the pharmaceutical industry and in academia there has been an intense search for novel inhibitors to be developed as new… CONTINUE READING
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