Beta-receptor blockade decreases carnitine palmitoyl transferase I activity in dogs with heart failure.

Abstract

BACKGROUND Pharmacological inhibition of carnitine palmitoyl transferase I (CPT-I), the enzyme controlling the rate of fatty acid transport into the mitochondria, prevents the contractile dysfunction, myosin isozyme shift and deterioration in sarcoplasmic reticulum Ca2+ handling that occurs in rat models of left ventricular hypertrophy. In this study we… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.