Beta-oxidized N-nitrosoalkylcarbamates as models for DNA alkylation by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters.

@article{Nagel1987BetaoxidizedNA,
  title={Beta-oxidized N-nitrosoalkylcarbamates as models for DNA alkylation by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters.},
  author={Dieter Nagel and Rick Lewis and Margaret G. Fischer and K H Stansbury and Katherine Stepan and Terence A. Lawson},
  journal={IARC scientific publications},
  year={1987},
  volume={84},
  pages={71-4}
}
A single dose of N-nitrosobis(2-oxopropyl)amine (NDOPA) can selectively induce pancreatic-duct adenocarcinomas in Syrian hamsters. Multiple doses or a higher single dose can induce tumours of the liver and other organs. Our earlier studies employing NDOPA systematically labelled with 14C in the three-carbon chain showed that hamster pancreatic DNA is almost… CONTINUE READING