Beta-oxidation of 2-ethyl-5-carboxypentyl phthalate in rodent liver.

@article{Albro1987BetaoxidationO2,
  title={Beta-oxidation of 2-ethyl-5-carboxypentyl phthalate in rodent liver.},
  author={Phillip W. Albro and Jean T. Corbett and Joanna L. Schroeder and Judy K. Reddy},
  journal={Biochimica et biophysica acta},
  year={1987},
  volume={923 2},
  pages={
          196-205
        }
}

Measurement of eight urinary metabolites of di(2-ethylhexyl) phthalate as biomarkers for human exposure assessment

Differences were found between the DEHP metabolite profile between this adult population and that of six neonates exposed to high doses of DEHP through extensive medical treatment.

Effects of chronic di(2-ethylhexyl) phthalate intake on the secretion and removal rate of triglyceride-rich lipoproteins in rats.

  • N. MocchiuttiC. Bernal
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1997

Regulations and Advisories

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Metabolism of di(2-ethylhexyl)phthalate.

References

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Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug.

Comparative morphometric and biochemical data from rats treated with varying dose levels of ciprofibrate, a hypolipidemic drug, and di(2-ethylhexyl) phthalate, and the widely used plasticizers, indicate that the hepatocarcinogenic potency of these agents is correlatable with their ability to induce peroxisome proliferation,peroxisomal beta-oxidation and PPA-80.

Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid).

The molecular weights and spectral properties of these cytochrome P-450 fractions are reported, along with the phenobarbitone-induced form of the enzyme and the nature of the cytochromes induced by clofibrate pretreatment are discussed in the terms of possible haemoprotein heterogeneity.

Pharmacokinetics, interactions with macromolecules and species differences in metabolism of DEHP.

Radioactivity from carbonyl-labeled DEHP did not associate with purified protein, RNA or DNA from rat liver in vivo, and the apparent binding from DEHP and MEHP was not exchangeable, but was not proven to be covalent.