Beta-like importins mediate the nuclear translocation of mitogen-activated protein kinases.

@article{Zehorai2014BetalikeIM,
  title={Beta-like importins mediate the nuclear translocation of mitogen-activated protein kinases.},
  author={Eldar Zehorai and Rony Seger},
  journal={Molecular and cellular biology},
  year={2014},
  volume={34 2},
  pages={259-70}
}
The rapid nuclear translocation of signaling proteins upon stimulation is important for the regulation of de novo gene expression. We have studied the stimulated nuclear shuttling of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases (MAPKs) and found that they translocate into the nucleus in a Ran-dependent, but NLS- or NTS-independent, manner, unrelated to their catalytic activity. We show that this translocation involves three β-like importins, importins 3, 7, and 9… CONTINUE READING

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