Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB.

  title={Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB.},
  author={Guang Zhi Dong and Eun Taex Oh and Hyemi Lee and Moon Taek Park and Chang Won Song and Heon Joo Park},
  journal={Experimental & molecular medicine},
  volume={42 5},
Anticancer effects of beta-lapachone (beta-lap) are due to generation of ROS and metabolic catastrophes as a result of NAD(P)H:quinone oxidoreductase (NQO1)-mediated futile cycling between the oxidized and reduced forms of beta-lap. It has been shown that NQO1 is also essential for the TNF-induced activation of NF-kappaB and that beta-lap suppresses the TNF… CONTINUE READING