Beta-lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types.

@article{Humeniuk2002BetalactamasesOK,
  title={Beta-lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types.},
  author={Christel Humeniuk and Guillaume Arlet and Val{\'e}rie Gautier and Patrick Grimont and R. Labia and Alain Philippon},
  journal={Antimicrobial agents and chemotherapy},
  year={2002},
  volume={46 9},
  pages={3045-9}
}
Kluyvera ascorbata produces a beta-lactamase that results in an atypical susceptibility pattern, including low-level resistance to penicillins, cephalothin, and cefuroxime, but this resistance is reversed by clavulanate. Ten nucleotide sequences of the corresponding gene, bla(KLUA), were obtained and were found to have minor variations (96 to 100%). Otherwise, bla(KLUA) was found to be similar (95 to 100%) to some plasmid-encoded CTX-M-type beta-lactamases. Finally, mobilization of bla(KLUA) on… CONTINUE READING