Beta-lactam resistance in Aeromonas spp. caused by inducible beta-lactamases active against penicillins, cephalosporins, and carbapenems.

@article{Bakken1988BetalactamRI,
  title={Beta-lactam resistance in Aeromonas spp. caused by inducible beta-lactamases active against penicillins, cephalosporins, and carbapenems.},
  author={Johan S. Bakken and Christine C. Sanders and Richard B. Clark and Makoto Hori},
  journal={Antimicrobial agents and chemotherapy},
  year={1988},
  volume={32 9},
  pages={
          1314-9
        }
}
Use of cefoperazone in a patient with Aeromonas caviae in the respiratory tract selected a mutant that constitutively produced beta-lactamase. This mutant, in contrast to its parental strain with an inducible beta-lactamase, showed enhanced resistance to newer cephalosporins and aztreonam. This observation suggested that species of Aeromonas, like those of other genera with inducible beta-lactamases, may pose therapeutic problems associated with the rapid development of multiple beta-lactam… CONTINUE READING
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