Beta-lactam-based approach for the chemical programming of aldolase antibody 38C2.

Abstract

Irreversible chemical programming of monoclonal aldolase antibody (mAb) 38C2 has been accomplished with beta-lactam-equipped targeting modules. A model study was first performed with beta-lactam conjugated to biotin. This conjugate efficiently and selectively modified the catalytic site lysine (LysH93) of mAb 38C2. We then conjugated a beta-lactam to a… (More)
DOI: 10.1016/j.bmcl.2009.01.028

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@article{Gavrilyuk2009BetalactambasedAF, title={Beta-lactam-based approach for the chemical programming of aldolase antibody 38C2.}, author={Julia I Gavrilyuk and Ulrich Wuellner and Carlos F. Barbas}, journal={Bioorganic & medicinal chemistry letters}, year={2009}, volume={19 5}, pages={1421-4} }