• Corpus ID: 1350891

Beta-lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane.

@article{Tsuji1987BetalactamAA,
  title={Beta-lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane.},
  author={Akira Tsuji and Ikumi Tamai and Hideki Hirooka and Tetsuya Terasaki},
  journal={Biochemical pharmacology},
  year={1987},
  volume={36 4},
  pages={
          565-7
        }
}
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It is shown that cefixime transport mediated by the intestinal H+-coupled peptide transporter PEPT1 leads to intracellular acidification, and changes in Ca2+in levels affect pH regulatory systems, such as apical Na+ and H+ exchange, and thereby alter the H+ gradient that serves as the driving force for uptake of β-lactams into intestinal epithelial cells.
Study on Regulation of Pharmacokinetics of Drugs Based on the Membrane Transport Mechanisms
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