• Corpus ID: 1350891

Beta-lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane.

  title={Beta-lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane.},
  author={Akira Tsuji and Ikumi Tamai and Hideki Hirooka and Tetsuya Terasaki},
  journal={Biochemical pharmacology},
  volume={36 4},
Effects of Amlodipine on the Oral Bioavailability of Cephalexin and Cefuroxime Axetil in Healthy Volunteers
The authors conclude that AML possesses an enhancement effect in β‐lactam antibiotic bioavailability (in this case, LEX), and this interaction may be specific to the peptidomimetic β‐ lactam antibiotics.
Inhibition of oligopeptide transporter suppress growth of human pancreatic cancer cells.
  • Keisuke Mitsuoka, Y. Kato, A. Tsuji
  • Biology, Chemistry
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2010
PEPT1-Mediated Cefixime Uptake into Human Intestinal Epithelial Cells Is Increased by Ca2+ Channel Blockers
It is shown that cefixime transport mediated by the intestinal H+-coupled peptide transporter PEPT1 leads to intracellular acidification, and changes in Ca2+in levels affect pH regulatory systems, such as apical Na+ and H+ exchange, and thereby alter the H+ gradient that serves as the driving force for uptake of β-lactams into intestinal epithelial cells.
Study on Regulation of Pharmacokinetics of Drugs Based on the Membrane Transport Mechanisms
It is demonstrated that several drugs are transported by the tissuespecific transporters in intestinal and renal epithelial cells, hepatocytes and brain capillary endothelial cells which form the blood-brain barrier, demonstrating that it would be possible to expect tissue selective delivery of drugs by utilizing transporter which have different characteristics among tissues.