Beta-lactam antibiotic therapy in febrile granulocytopenic patients. A randomized trial comparing cefoperazone plus piperacillin, ceftazidime plus piperacillin, and imipenem alone.

@article{Winston1991BetalactamAT,
  title={Beta-lactam antibiotic therapy in febrile granulocytopenic patients. A randomized trial comparing cefoperazone plus piperacillin, ceftazidime plus piperacillin, and imipenem alone.},
  author={Drew J. Winston and Winston G. Ho and David Bruckner and Richard E. Champlin},
  journal={Annals of internal medicine},
  year={1991},
  volume={115 11},
  pages={849-59}
}
OBJECTIVE To compare the efficacy, toxicity, and cost-effectiveness of double beta-lactam therapy with monotherapy. DESIGN A randomized, controlled trial. PATIENTS Febrile, granulocytopenic patients (429). INTERVENTIONS Patients were randomly assigned to receive iv cefoperazone (3 g every 12 hours) plus piperacillin (75 mg/kg body weight every 6 hours), ceftazidime (2 g every 8 hours) plus piperacillin (75 mg/kg every 6 hours), or imipenem alone (1.0 g or 0.5 g every 6 hours). Patients… CONTINUE READING