Beta-hydroxy-beta-methylbutyrate supplementation in health and disease: a systematic review of randomized trials

@article{Molfino2013BetahydroxybetamethylbutyrateSI,
  title={Beta-hydroxy-beta-methylbutyrate supplementation in health and disease: a systematic review of randomized trials},
  author={Alessio Molfino and Gianfranco Gioia and Filippo Rossi Fanelli and Maurizio Muscaritoli},
  journal={Amino Acids},
  year={2013},
  volume={45},
  pages={1273-1292}
}
Beta-hydroxy-beta-methylbutyrate (HMB), a metabolite of the branched-chain amino acid leucine, is extensively used by athletes and bodybuilders in order to increase strength, muscle mass and exercise performance. We performed a systematic review of the clinical literature on the effectiveness of HMB supplementation in healthy and pathological conditions (i.e. training programs, aging, acute and chronic diseases, and after bariatric surgery). We reviewed all clinical trials indexed in Medline… Expand
Is β-hydroxy β-methylbutyrate an effective anabolic agent to improve outcome in older diseased populations?
TLDR
The older diseased population might benefit from dietary HMB because of its established positive properties as well as its long lasting (pharmacological) effect. Expand
Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults: a systematic review and meta-analysis.
TLDR
Beta-hydroxy-beta-methylbutyrate supplementation contributed to preservation of muscle mass in older adults and may be useful in the prevention of muscle atrophy induced by bed rest or other factors. Expand
Supplementation with beta-hydroxy-beta-methylbutyrate impacts glucose homeostasis and increases liver size in trained mice.
  • I. Schadock, Barbara G Freitas, +10 authors C. Barros
  • Medicine, Chemistry
  • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 2018
TLDR
It is confirmed that HMB supplementation associated with intensive training protocol drives changes in glucose homeostasis and liver metabolism in mice. Expand
Effect of Oral Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Physical Performance in Healthy Old Women Over 65 Years: An Open Label Randomized Controlled Trial
TLDR
A nutritional supplement containing 1.5 g of calcium HMB for 8 weeks in healthy elderly women had no significant effects on SPPB, but did significantly improve several muscle strength and physical performance parameters. Expand
Effect of administration of β-hydroxy-β-methyl butyrate-enriched formula after liver transplantation: A pilot randomized controlled trial.
TLDR
Postoperative administration of HMB-enriched formula with rehabilitation significantly increased GS at 1 and 2 mo and SMI at 2Mo and shortened postoperative hospital LOS after LDLT, andPostoperative hospital length of stay (LOS) was significantly shorter. Expand
Effects of Protein, Essential Amino Acids, B-Hydroxy B-Methylbutyrate, Creatine, Dehydroepiandrosterone and Fatty Acid Supplementation on Muscle Mass, Muscle Strength and Physical Performance in Older People Aged 60 Years and Over. A Systematic Review of the Literature
TLDR
The overall quality of the evidence was judged to be low or very low using the GRADE system and well designed and appropriately powered RCTs are needed to provide evidence for appropriate clinical recommendations. Expand
No effect of HMB or α-HICA supplementation on training-induced changes in body composition
Abstract β-hydroxy-β-methylbutyrate (calcium: HMB-Ca and free acid: HMB-FA) and α-hydroxyisocaproic acid (α-HICA) are leucine metabolites that have been proposed to improve body composition andExpand
The Effects of Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Recovery Following Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis
TLDR
The current evidence revealed a time-dependent effect of HMB in reducing LDH and CK serum levels among adults, and HMB may be seen as a priority muscle damage recovery agent in interventions. Expand
Role of Oral Nutritional Supplements Enriched with B-hydroxy-B-Methylbutyrate in Maintaining Muscle Function and Improving Clinical Outcomes in Various Clinical Settings
TLDR
Overall, current evidence suggests that therapeutic nutrition such as HP-ONS+HMB seems to be a promising tool to mitigate the decline in muscle mass and preserve muscle function, especially during hospital rehabilitation and recovery. Expand
Effect of supplementation with a combination of l ‐arginine, l ‐glutamine, and hydroxy methyl butyrate on cachexia: A systematic review
TLDR
A systematic review of available studies assessing the effect of Arg, Glutamine, and HMB supplementation on improving body weight and muscle mass in those with pathological conditions shows that this combination can improve fat free mass, weight and immune function in cachexia and morbid weight loss patients. Expand
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Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women.
TLDR
It is indicated that daily supplementation of beta-hydroxy-beta-methylbutyrate, arginine, and lysine for 12 wk positively alters measurements of functionality, strength, fat-free mass, and protein synthesis, suggesting that the strategy of targeted nutrition has the ability to affect muscle health in elderly women. Expand
β-Hydroxy-β-Methylbutyrate (HMB) Supplementation in Humans Is Safe and May Decrease Cardiovascular Risk Factors
TLDR
Objective data collected across nine experiments indicate that HMB can be taken safely as an ergogenic aid for exercise and that objective measures of health and perception of well-being are generally enhanced. Expand
beta-hydroxy-beta-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors.
TLDR
Objective data collected across nine experiments indicate that HMB can be taken safely as an ergogenic aid for exercise and that objective measures of health and perception of well-being are generally enhanced. Expand
Effect of β-hydroxy-β-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
TLDR
It is indicated that daily supplementation of β-hydroxy-β-methylbutyrate, arginine, and lysine for 12 wk positively alters measurements of functionality, strength, fat-free mass, and protein synthesis, suggesting that the strategy of targeted nutrition has the ability to affect muscle health in elderly women. Expand
Beta-hydroxy-beta-methylbutyrate (HMB) supplementation does not affect changes in strength or body composition during resistance training in trained men.
TLDR
The data indicate that 6 weeks of HMB supplementation in either SH or TRH form does not influence changes in strength and body composition in response to resistance training in strength-trained athletes. Expand
Supplementation with a combination of beta-hydroxy-beta-methylbutyrate (HMB), arginine, and glutamine is safe and could improve hematological parameters.
TLDR
Results show that HMB, arginine, and glutamine can be safely used to treat muscle wasting associated with AIDS and cancer and are associated with an improvement in emotional profile and increased red blood cells, hemoglobin, hematocrit, lymphocytes, and eosinophils. Expand
Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage
TLDR
Investigation of the acute and timing effects of oral HMB supplementation on serum creatine kinase (CK), lactate dehydrogenase (LDH), muscle soreness, and maximal voluntary contraction found no clear acute or timing effects. Expand
beta-hydroxy-beta-methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humans.
TLDR
HMB plasma levels peak within 60 to 120 min depending on the amount of HMB consumed and whether glucose is consumed with HMB, and the plasma half-life is approximately 2.5 hr. Expand
Short-term β-hydroxy-β-methylbutyrate supplementation does not reduce symptoms of eccentric muscle damage
TLDR
Compared to a placebo condition, short-term supplementation with 40mg/kg bodyweight/day of HMB had no beneficial effect on a range of symptoms associated with eccentric muscle damage. Expand
Effects of calcium beta-hydroxy-beta-methylbutyrate (HMB) supplementation during resistance-training on markers of catabolism, body composition and strength.
TLDR
Results indicate that 28 d of HMB supplementation during resistance-training does not reduce catabolism or affect training-induced changes in body composition and strength in experienced resistance-trained males. Expand
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