Beta-hydroxy-beta-methylbutyrate ameliorates aging effects in the dendritic tree of pyramidal neurons in the medial prefrontal cortex of both male and female rats

@article{Kougias2016BetahydroxybetamethylbutyrateAA,
  title={Beta-hydroxy-beta-methylbutyrate ameliorates aging effects in the dendritic tree of pyramidal neurons in the medial prefrontal cortex of both male and female rats},
  author={Daniel G Kougias and Suzanne O. Nolan and Wendy A. Koss and Taehyeong Kim and Emily R. Hankosky and Joshua M. Gulley and Janice M Juraska},
  journal={Neurobiology of Aging},
  year={2016},
  volume={40},
  pages={78-85}
}
Beta-hydroxy-beta-methylbutyrate (HMB), a supplement commonly used to maintain muscle in elderly and clinical populations, has been unexplored in the aging brain. In both healthy aging humans and rat models, there are cognitive deficits associated with age-related dendritic shrinkage within the prefrontal cortex. The present study explores the effects of relatively short- and long-term (7 and 31 weeks) oral HMB supplementation starting at 12 months of age in male and female rats on the… Expand
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Purpose of review b-Hydroxy b-methylbutyrate (HMB) has been used for many years in athletes for muscle buildup and strength, and endurance enhancement. In recent years, its interest quickly expandedExpand
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Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions
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  • Medicine
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Sarcopenia in the elderly: from clinical aspects to therapeutic options
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