Beta-hydroxy-beta-methylbutyrate ameliorates aging effects in the dendritic tree of pyramidal neurons in the medial prefrontal cortex of both male and female rats

  title={Beta-hydroxy-beta-methylbutyrate ameliorates aging effects in the dendritic tree of pyramidal neurons in the medial prefrontal cortex of both male and female rats},
  author={Daniel G Kougias and Suzanne O. Nolan and Wendy A. Koss and Taehyeong Kim and Emily R. Hankosky and Joshua M. Gulley and Janice M Juraska},
  journal={Neurobiology of Aging},
Beta-hydroxy-beta-methylbutyrate (HMB), a supplement commonly used to maintain muscle in elderly and clinical populations, has been unexplored in the aging brain. In both healthy aging humans and rat models, there are cognitive deficits associated with age-related dendritic shrinkage within the prefrontal cortex. The present study explores the effects of relatively short- and long-term (7 and 31 weeks) oral HMB supplementation starting at 12 months of age in male and female rats on the… Expand
Beta-hydroxy-beta-methylbutyrate (HMB) ameliorates age-related deficits in water maze performance, especially in male rats
HMB supplementation prevented the age-related decrement in water maze performance, especially in male rats, and was ameliorated in HMB-treated males during training and in both sexes during probe trial performance. Expand
Effects of β-hydroxy-β-methyl butyrate on working memory and cognitive flexibility in an animal model of aging
It is suggested that daily nutritional supplementation with HMB facilitates learning and improves working memory performance and may therefore be an effective tool to combat this undesirable feature of the aging process. Expand
Impact of β-hydroxy β-methylbutyrate (HMB) on age-related functional deficits in mice
While short‐term HMB supplementation does not appear to affect neurogenesis or cognitive function in young or aged mice, HMB may maintain muscle strength in aged mice in a manner dependent on mMSC function, which selectively enhances MSC function both in vivo and in vitro. Expand
Structural and molecular correlates of cognitive aging in the rat
It is confirmed that, as a group, old  rats display poorer spatial learning and behavioral flexibility than younger adults, and for younger individuals “bigger is better” is a more appropriate aphorism for older subjects. Expand
Is β-hydroxy β-methylbutyrate an effective anabolic agent to improve outcome in older diseased populations?
The older diseased population might benefit from dietary HMB because of its established positive properties as well as its long lasting (pharmacological) effect. Expand
Health Benefits of β-Hydroxy-β-Methylbutyrate (HMB) Supplementation in Addition to Physical Exercise in Older Adults: A Systematic Review with Meta-Analysis
Results showed that HMB supplementation in addition to physical exercise has no or fairly low impact in improving body composition, muscle strength, or physical performance in adults aged 50 to 80 years, compared to exercise alone. Expand
Purpose of review b-Hydroxy b-methylbutyrate (HMB) has been used for many years in athletes for muscle buildup and strength, and endurance enhancement. In recent years, its interest quickly expandedExpand
A role for nutritional intervention in addressing the aging neuromuscular junction.
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Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions
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  • Medicine
  • Journal of cachexia, sarcopenia and muscle
  • 2017
The evidence for the rationale to use HMB as a nutritional supplement to exert beneficial effects on muscle mass and function in various conditions of health and disease is examined. Expand
Sarcopenia in the elderly: from clinical aspects to therapeutic options
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The effects of long-term treatment with estradiol and medroxyprogesterone acetate on tyrosine hydroxylase fibers and neuron number in the medial prefrontal cortex of aged female rats.
Results indicate that long-term hormone treatments alter dopaminergic fibers and potentially the functioning of the aging mPFC. Expand
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Aging and sex influence the anatomy of the rat anterior cingulate cortex
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Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats
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Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory.
Results indicated that spatial memory decreased with age and that chronic [D-Ala2]-GHRH prevented this age-related decrement, and suggested that growth hormone and IGF-1 have important effects on brain function, and that these changes can be reversed by the chronic administration of GHRH. Expand
Correlation of cognitive performance and morphological changes in neocortical pyramidal neurons in aging
The data suggest that both cholinergic atrophy and an imbalance towards inhibition may contribute to the observed age-associated behavioral impairment. Expand
Chronic supplementation of beta-hydroxy-beta methylbutyrate (HMβ) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in rats.
The data presented herein extend the body of evidence on the potential role of HMβ-treatment in stimulating GH/IGF-I axis activity and induces an apparent insulin resistance state which might limit the beneficial aspects of the former results, at least in rats under normal nutritional status and health conditions. Expand
Glucose and age-related changes in memory
  • P. E. Gold
  • Medicine, Psychology
  • Neurobiology of Aging
  • 2005
The findings suggest that age-related changes in both peripheral and central glucose physiology contribute to age- related impairments in memory. Expand
Life‐span dendritic and spine changes in areas 10 and 18 of human cortex: A quantitative golgi study
Dendritic neuropil is a sensitive indicator of the aging process and may exhibit regional cortical variations. The present study examined regional differences and age‐related changes in the basilarExpand