Beta-globin haplotype and XmnI polymorphism at position G (gamma)-158 and HbF production in Fanconi's anemia.

@article{Rosatelli1992BetaglobinHA,
  title={Beta-globin haplotype and XmnI polymorphism at position G (gamma)-158 and HbF production in Fanconi's anemia.},
  author={Maria Cristina Rosatelli and Ciğdem Altay and Reyhan Oner and Giovan Battista Leoni and B Moi and G Atzori and Antonio Cao},
  journal={Haematologica},
  year={1992},
  volume={77 2},
  pages={106-9}
}
BACKGROUND Patients with aplastic anemia show to a variable degree an increase of the red blood cell volume and percentage of HbF. The extent of HbF reactivation in sickle cell anemia and thalassemia major is related to the presence of XmnI polymorphism at -158 G (gamma). In this study, we have investigated whether in Fanconi's anemia the increase of the HbF is also related to the XmnI polymorphism. METHODS Restriction site polymorphisms in the beta-globin gene cluster were analyzed to define… CONTINUE READING