Beta-globin YAC transgenes exhibit uniform expression levels but position effect variegation in mice.

Abstract

Expression of a construct integrated at different genomic locations often varies because of position effects that have been subcategorized as stable (decreased level of expression) and variegating (decreased proportion of expressing cells). It is well established that locus control regions (LCRs) generally overcome position effects in transgenes. However… (More)

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@article{Alami2000BetaglobinYT, title={Beta-globin YAC transgenes exhibit uniform expression levels but position effect variegation in mice.}, author={Raouf Alami and John M. Greally and Kyouko Tanimoto and Sung-min Hwang and Ying Feng and Jerome Engel and Steven N. Fiering and Eric E. Bouhassira}, journal={Human molecular genetics}, year={2000}, volume={9 4}, pages={631-6} }