Beta gamma-subunit activation of G-protein-regulated phospholipase C.

  title={Beta gamma-subunit activation of G-protein-regulated phospholipase C.},
  author={Jos{\'e} Luis Boyer and Gary L. Waldo and T. Kendall Harden},
  journal={The Journal of biological chemistry},
  volume={267 35},
The availability of purified G alpha 11 and the G-protein-regulated phospholipase C from turkey erythrocytes has allowed an examination of the direct effects of G-protein beta gamma-subunit on the components of the inositol lipid signaling system. Reconstitution of purified turkey erythrocyte or bovine brain beta gamma-subunit into phospholipid vesicles containing G alpha 11 inhibited AlF4- induced activation of phospholipase C. However, beta gamma-subunit at higher concentrations increased… CONTINUE READING
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