Beta-funaltrexamine affects cocaine self-administration in rats responding on a progressive ratio schedule of reinforcement.

@article{Ward2003BetafunaltrexamineAC,
  title={Beta-funaltrexamine affects cocaine self-administration in rats responding on a progressive ratio schedule of reinforcement.},
  author={Sara Jane Ward and Thomas J Martin and David C. S. Roberts},
  journal={Pharmacology, biochemistry, and behavior},
  year={2003},
  volume={75 2},
  pages={301-7}
}
Many studies have shown interactions between mu-opiates and the mesolimbic dopamine (DA) system. Mu-opiate receptor antagonists have been reported to either increase or decrease the rate of cocaine self-administration, and the interpretation of these data has been difficult. In an attempt to further characterize and localize the effect of opiate receptor blockade on the reinforcing effects of cocaine, the mu-opiate irreversible antagonist beta-funaltrexamine (betaFNA) was administered locally… CONTINUE READING
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