Beta-estradiol-induced decrease in IL-12 and TNF-alpha expression suppresses macrophage functions in the course of Listeria monocytogenes infection in mice.

@article{Salem1999BetaestradiolinducedDI,
  title={Beta-estradiol-induced decrease in IL-12 and TNF-alpha expression suppresses macrophage functions in the course of Listeria monocytogenes infection in mice.},
  author={Mohamed Labib Salem and Goro Matsuzaki and Gamal A. Madkour and Kikuo Nomoto},
  journal={International journal of immunopharmacology},
  year={1999},
  volume={21 8},
  pages={481-97}
}
Mice treated with a contraceptive dose of beta-estradiol (E2) demonstrated changes in their macrophage (Mphi) number and functions. While E2 increased and decreased the Mphi number in PBMC and PEC respectively, it enhanced the in vitro phagocytosis of FITC-labeled beads by both cells. E2 treatment also enhanced the phagocytic function of Mphi as assessed by the in vivo carbon clearance assay. In contrast, the in vitro intracellular killing function of adherent cells in peritoneal exudate cells… CONTINUE READING

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