Beta-endorphin inhibits glucose production in the conscious dog.

  title={Beta-endorphin inhibits glucose production in the conscious dog.},
  author={Paul M. Radosevich and P. E. V. Williams and J McRae and William W. Lacy and David N. Orth and Naji N Abumrad},
  journal={The Journal of clinical investigation},
  volume={73 4},
The effect of human beta-endorphin (h beta E) infusion (0.2 mg/h) on glucose homeostasis was studied in 10 conscious overnight fasted dogs in which endocrine pancreatic function was fixed at basal levels with somatostatin plus intraportal replacement of basal insulin and glucagon. h beta E caused a fall in plasma glucose from 107 +/- 5 to 76 +/- 6 mg/dl by 3 h (P less than 0.01). This was due to a 25% fall in tracer-determined glucose production (Ra; P less than 0.01). A significantly larger… Expand
Central effects of beta-endorphins on glucose homeostasis in the conscious dog.
It is concluded that beta-endorphin acts centrally to cause hyperglycemia by stimulating sympathetic outflow and the pituitary-adrenal axis. Expand
Beta endorphin modulation of the glucoregulatory effects of repeated epinephrine infusion in alloxan-diabetic and normal dogs
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Effect of opiate-receptor blockade on normoglycemic and hypoglycemic glucoregulation.
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Lack of effect of beta-endorphin on basal or glucagon-stimulated hepatic glucose production in vitro.
The results suggest that reported in vivo effects of beta-endorphin to inhibit hepatic glucose production were either indirect or centrally mediated. Expand
Hormonal and metabolic responses to intracarotid and intrajugular infusion of beta-endorphin in normal dogs.
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Effects of insulin-induced hypoglycemia on plasma and cerebrospinal fluid levels of ir-β-endorphins, ACTH, cortisol, norepinephrine, insulin and glucose in the conscious dog
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Effect of Naloxon on Counter Insulin Hormone Secretion in Insulin-Induced Hypoglycemia
It is concluded that endogenous opiates may be involved in the feedback regulation of secretion of ACTH and GH during hypoglycemia either at hypophysis or hypothalamus, and involved in glucose homeostasis via a certain direct mechanism other than regulation of counter hormone secretion. Expand
Endogenous opioids modulate the effect of cholecystokinin on insulin release in dogs
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