Beta-endorphin inhibits glucose production in the conscious dog.

@article{Radosevich1984BetaendorphinIG,
  title={Beta-endorphin inhibits glucose production in the conscious dog.},
  author={Paul M. Radosevich and P. E. V. Williams and J McRae and William W. Lacy and David N. Orth and Naji N Abumrad},
  journal={The Journal of clinical investigation},
  year={1984},
  volume={73 4},
  pages={
          1237-41
        }
}
The effect of human beta-endorphin (h beta E) infusion (0.2 mg/h) on glucose homeostasis was studied in 10 conscious overnight fasted dogs in which endocrine pancreatic function was fixed at basal levels with somatostatin plus intraportal replacement of basal insulin and glucagon. h beta E caused a fall in plasma glucose from 107 +/- 5 to 76 +/- 6 mg/dl by 3 h (P less than 0.01). This was due to a 25% fall in tracer-determined glucose production (Ra; P less than 0.01). A significantly larger… Expand
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