Beta edge strands in protein structure prediction and aggregation.

  title={Beta edge strands in protein structure prediction and aggregation.},
  author={Jennifer A. Siepen and Sheena E Radford and David R. Westhead},
  journal={Protein science : a publication of the Protein Society},
  volume={12 10},
It is well established that recognition between exposed edges of beta-sheets is an important mode of protein-protein interaction and can have pathological consequences; for instance, it has been linked to the aggregation of proteins into a fibrillar structure, which is associated with a number of predominantly neurodegenerative disorders. A number of protective mechanisms have evolved in the edge strands of beta-sheets, preventing the aggregation and insolubility of most natural beta-sheet… CONTINUE READING