Beta-ecdysone has bone protective but no estrogenic effects in ovariectomized rats.

@article{SeidlovWuttke2010BetaecdysoneHB,
  title={Beta-ecdysone has bone protective but no estrogenic effects in ovariectomized rats.},
  author={Dana Seidlov{\'a}-Wuttke and David Christel and Priya Kapur and Ba Tiep Nguyen and Hubertus Jarry and Wolfgang Wuttke},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2010},
  volume={17 11},
  pages={884-9}
}
Estrogens exert beneficial effects in the bone. Their chronic use however bares several risks. Therefore intensive search for non-estrogenic, bone protective compounds is going on. We observed that an extract of Tinospora cordifolia has antiosteoporotic effects and identified 20-OH-Ecdysone (beta-Ecdysone=Ecd) as a possible candidate for this action. Ovariectomized (ovx) rats were treated orally over 3 months with no Ecd (control) or 18, 57 or 121 mg Ecd/day/animal. Estradiol-17beta benzoate… CONTINUE READING
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