Beta-cluster haplotypes, alpha-gene status, and hematological data from SS, SC, and S-beta-thalassemia patients in southern California.

@article{Schroeder1989BetaclusterHA,
  title={Beta-cluster haplotypes, alpha-gene status, and hematological data from SS, SC, and S-beta-thalassemia patients in southern California.},
  author={Walter A Schroeder and Darleen R. Powars and Leslie M. Kay and Lawrence S. Chan and V B Huynh and Joan Balog Shelton and J. Roger Shelton},
  journal={Hemoglobin},
  year={1989},
  volume={13 4},
  pages={325-53}
}
The beta-gene-cluster haplotype and alpha-gene status were determined for 221 patients with sickle cell anemia, 41 with SC disease, and 21 with S-beta-thalassemia. Among SS patients, eleven beta S haplotypes were found in 21 combinations. Three haplotypes--the Benin (Ben) [---+-], the Central African Republic (CAR) [+---+], and the Senegal (Sen) [+- ]--comprise 61%, 21%, and 10% of the chromosomes, respectively. Cleavage at the Xmn I site 5' to the G gamma gene was observed only when the… CONTINUE READING
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