Beta clamp directs localization of mismatch repair in Bacillus subtilis.

@article{Simmons2008BetaCD,
  title={Beta clamp directs localization of mismatch repair in Bacillus subtilis.},
  author={Lyle A Simmons and Bryan Davies and Alan D Grossman and Graham C Walker},
  journal={Molecular cell},
  year={2008},
  volume={29 3},
  pages={291-301}
}
MutS homologs function in several cellular pathways including mismatch repair (MMR), the process by which mismatches introduced during DNA replication are corrected. We demonstrate that the C terminus of Bacillus subtilis MutS is necessary for an interaction with beta clamp. This interaction is required for MutS-GFP focus formation in response to mismatches. Reciprocally, we show that a mutant of the beta clamp causes elevated mutation frequencies and is reduced for MutS-GFP focus formation… CONTINUE READING