Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release.

@article{Franklin2005BetacellSP,
  title={Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release.},
  author={Isobel Franklin and Jesper Gromada and Asllan Gjinovci and Sten Theander and Claes B Wollheim},
  journal={Diabetes},
  year={2005},
  volume={54 6},
  pages={1808-15}
}
Glucagon, secreted from islet alpha-cells, mobilizes liver glucose. During hyperglycemia, glucagon secretion is inhibited by paracrine factors from other islet cells, but in type 1 and type 2 diabetic patients, this suppression is lost. We investigated the effects of beta-cell secretory products zinc and insulin on isolated rat alpha-cells, intact islets, and perfused pancreata. Islet glucagon secretion was markedly zinc sensitive (IC(50) = 2.7 micromol/l) more than insulin release (IC(50) = 10… CONTINUE READING

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