Beta-cell maturation leads to in vitro sensitivity to cytotoxins.


Pancreatic beta-cells are more sensitive to several toxins (e.g., streptozotocin, alloxan, cytokines) than the other three endocrine cell types in the islets of Langerhans. Cytokine-induced free radicals in beta-cells may be involved in beta-cell-specific destruction in type 1 diabetes. To investigate if this sensitivity represents an acquired trait during… (More)


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@article{Nielsen1999BetacellML, title={Beta-cell maturation leads to in vitro sensitivity to cytotoxins.}, author={K. Nielsen and Allan Ertman Karlsen and Martina Deckert and O. D. Madsen and Palle Serup and Tom Mandrup-Poulsen and Jorn Nerup}, journal={Diabetes}, year={1999}, volume={48 12}, pages={2324-32} }