Beta-cell failure in type 2 diabetes mellitus.

  title={Beta-cell failure in type 2 diabetes mellitus.},
  author={Cristina Lencioni and R. Miguel Lupi and Stefano Del Prato},
  journal={Current diabetes reports},
  volume={8 3},
Diabetes mellitus has been defined as a "group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both" and encompasses a wide range of heterogeneous conditions. Common type 2 diabetes mellitus (T2DM) results from a combination of genetic and acquired factors. However, lifestyle factors, particularly overeating and physical inactivity, are the major clinical determinants of T2DM. Insulin resistance is a common feature of T2DM… CONTINUE READING
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