Beta-cell development and turnover during prenatal life in humans.

  title={Beta-cell development and turnover during prenatal life in humans.},
  author={Juris J Meier and Christina U. K{\"o}hler and Bacel Alkhatib and Consolato M Sergi and Theresa Junker and Harald H. Klein and Wolfgang Schmidt and H. -W. Fritsch},
  journal={European journal of endocrinology},
  volume={162 3},
INTRODUCTION beta-cell regeneration is an area under active investigation for the future treatment of diabetes, but little is known about the patterns and dynamics of prenatal beta-cell development in humans. In particular, the quantitative changes in beta-cell mass in the developing pancreas have not been elucidated in detail. We addressed the following questions in prenatal humans: i) what is the timing of beta-cell occurrence and islet growth? ii) What are the dynamics of beta-cell… CONTINUE READING


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