Beta-cell deterioration during diabetes: what's in the gun?

  title={Beta-cell deterioration during diabetes: what's in the gun?},
  author={R. Paul Robertson},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={20 8},
Clinical management of patients with type 2 diabetes (T2D) successfully prevents extreme hyperglycemia but does not precisely control glucose levels throughout the day. The pathogenesis of T2D is akin to a double-barrel shotgun. The first trigger causes an explosion that sets genetic expression of the disease in motion; the second trigger discharges a host of environmental factors that worsen its clinical course. Candidate shells include glucolipotoxicity, cytokines, oxidative and endoplasmic… CONTINUE READING


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