Beta cell MHC class I is a late requirement for diabetes.

@article{HamiltonWilliams2003BetaCM,
  title={Beta cell MHC class I is a late requirement for diabetes.},
  author={Emma E Hamilton-Williams and Stephanie E. Palmer and Brett Charlton and Robyn Maree Slattery},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 11},
  pages={6688-93}
}
Type 1 diabetes occurs as a result of an autoimmune attack on the insulin-producing beta cells. Although CD8 T cells have been implicated both early and late in this process, the requirement for direct interaction between these cells and MHC class I on the beta cells has not been demonstrated. By using nonobese diabetic mice lacking beta cell class I expression, we show that both initiation and progression of insulitis proceeds unperturbed. However, without beta cell class I expression, the… CONTINUE READING