Beta-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone.

@article{Adachi2007BetacateninSP,
  title={Beta-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone.},
  author={Kazuhide Adachi and Zaman Mirzadeh and Masanori Sakaguchi and Toru Yamashita and Tania Nikolcheva and Yukiko Gotoh and Gary Peltz and Leyi Gong and Takeshi Kawase and Arturo Alvarez-Buylla and Hideyuki Okano and Kazunobu Sawamoto},
  journal={Stem cells},
  year={2007},
  volume={25 11},
  pages={
          2827-36
        }
}
The subventricular zone (SVZ) is the largest germinal zone in the mature rodent brain, and it continuously produces young neurons that migrate to the olfactory bulb. Neural stem cells in this region generate migratory neuroblasts via highly proliferative transit-amplifying cells. The Wnt/beta-catenin signaling pathway partially regulates the proliferation and neuronal differentiation of neural progenitor cells in the embryonic brain. Here, we studied the role of beta-catenin signaling in the… CONTINUE READING
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