Beta-catenin regulates positive selection of thymocytes but not lineage commitment.

  title={Beta-catenin regulates positive selection of thymocytes but not lineage commitment.},
  author={Qing Yu and Jyoti Misra Sen},
  journal={Journal of immunology},
  volume={178 8},
Positive selection and lineage commitment to the cytolytic or helper lineage of T cells result in coordinated expression of MHC class I-restricted TCR and CD8 coreceptor or MHC class II-restricted TCR and CD4 molecule. Positive selection signals also regulate the survival and generation of requisite numbers of cytolytic or Th cells. beta-Catenin is the major transcriptional cofactor of T cell factor and plays a role in thymocyte development. In this study, using mice expressing stabilized beta… CONTINUE READING


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