Beta-catenin mutations in human prostate cancer.


Beta-catenin plays essential roles in both intercellular adhesion and signal transduction. As a signaling molecule, beta-catenin supplies an activating domain to the T-cell factor/lymphoid enhancer-binding factor family of DNA-binding proteins and activates gene transcription. Posttranslational stabilization of beta-catenin, leading to elevated protein… (More)


Cite this paper

@article{Vller1998BetacateninMI, title={Beta-catenin mutations in human prostate cancer.}, author={Heinz V{\"o}ller and Cristina I. Truica and Edward P. Gelmann}, journal={Cancer research}, year={1998}, volume={58 12}, pages={2520-3} }