Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway.

@article{MirabelliPrimdahl1999BetacateninMA,
  title={Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway.},
  author={Laura Mirabelli-Primdahl and Robert Gryfe and Hyunsoo Kim and Anna Millar and Cristina Luceri and Darlene Dale and Eric J. Holowaty and Bharati Bapat and Steven Gallinger and Mark Redston},
  journal={Cancer research},
  year={1999},
  volume={59 14},
  pages={3346-51}
}
Some colorectal tumors with wild-type adenomatous polyposis coli gene have activating mutations in beta-catenin (encoded by CTNNB1) that result in decreased phosphorylation by GSK-3beta and increased signaling through the Tcf/Lef transcription factors. To investigate the relationship between CTNNB1 mutations and underlying pathways of genomic instability… CONTINUE READING