Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas.

@article{Samowitz1999BetacateninMA,
  title={Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas.},
  author={Wade S. Samowitz and Michael David Powers and Lisa N. Spirio and Friedel Nollet and Frans van Roy and Martha L. Slattery},
  journal={Cancer research},
  year={1999},
  volume={59 7},
  pages={
          1442-4
        }
}
Loss of serine or threonine phosphorylation sites from exon 3 of beta-catenin has been identified in approximately half of colorectal tumors which lack adenomatous polyposis coli (APC) mutations, but the overall contribution of beta-catenin mutations to sporadic colorectal tumorigenesis is unclear. We therefore used PCR to amplify and sequence exon 3 of beta-catenin from 202 sporadic colorectal tumors. Exon 3 beta-catenin mutations were identified in 6 of 48 small (< 1 cm) adenomas, 2 of 82… CONTINUE READING

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