Beta-catenin modulates the level and transcriptional activity of Notch1/NICD through its direct interaction.

@article{Jin2009BetacateninMT,
  title={Beta-catenin modulates the level and transcriptional activity of Notch1/NICD through its direct interaction.},
  author={Yun Hye Jin and Hangun Kim and Hyunkyung Ki and Ilhwan Yang and Narae Yang and Kwang Youl Lee and Nacksung Kim and H S Park and Kwonseop Kim},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1793 2},
  pages={290-9}
}
Wnt and Notch1 signaling pathways play an important role in a variety of biological processes including embryonic induction, the polarity of cell division, cell fate, and cell growth. Although there is evidence that the two main signaling pathways can modulate each other, the precise mechanism is not completely understood. This report shows that beta-catenin can regulate the level and transcriptional activity of the Notch1 and Notch1 intracellular domain (NICD). The in vivo and in vitro results… CONTINUE READING