Beta-carotene cleavage products after oxidation mediated by hypochlorous acid--a model for neutrophil-derived degradation.

@article{Sommerburg2003BetacaroteneCP,
  title={Beta-carotene cleavage products after oxidation mediated by hypochlorous acid--a model for neutrophil-derived degradation.},
  author={Olaf Sommerburg and C. D. Langhans and Juergen Arnhold and Michael Leichsenring and Costantino Salerno and Carlo Crif{\`o} and Georg Friedrich Hoffmann and K -M Debatin and Werner G. Siems},
  journal={Free radical biology & medicine},
  year={2003},
  volume={35 11},
  pages={1480-90}
}
After beta-carotene failed in certain clinical efficacy trials, there is evidence that the carotenoid might even be harmful, especially to smokers, when given in high dosages. These negative effects might be mediated in part also by carotenoid cleavage products (CPs) having a high reactivity towards biomolecules. The authors postulate that in certain tissues oxidative, nonenzymatic cleavage of carotenoids is carried out primarily by oxidants liberated by polymorphonuclear leukocytes (PML). In… CONTINUE READING
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